Translational Regulation During Aging of Neural Stem Cells

In the adult mouse brain, neural stem cells remain in a quiescent state, and activation of neural stem cells by chance allows new neurons to be generated. A decrease in the number of newborn neurons is considered to be one of the causes of age-related decline in brain functions such as memory and learning ability. Previous studies have shown that not only does the total number of neural stem cells decrease with age, but also quiescent neural stem cells cannot be activated. Many studies have focused on changes in the transcriptome of neural stem cells with aging, but no significant changes have been observed. Here, I focus on the change of translational regulation system during aging of neural stem cells.